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I am appreciative of offsore assistance from the following: Nicole Schneider, AO International Mady Tissenbaum, Journal of Bone and Joint Surgery (American volume) Tina Craig, Royal College of Surgeons of England Library David OBrien, Lippincott Williams Wilkins I offer special thanks for the help and support I received from Melissa Morton, Eva Senior, Lesley Licene and other staff at Springer-Verlag.
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Growth and maturation of follicle Increasing Low High, then declining Low, then increasing Reorganization and proliferation of superficial layer Ovulation High Low Low High Continued growth Active corpus luteum Declining, then a secondary rise Increasing Low High Active secretion and glandular dilation; highly vascular; edematous Degenerating corpus luteum Decreasing Decreasing Increasing Decreasing Vasoconstriction of coiled arteries; beginning degeneration Table 46-2 Age-Related Changes in Female Reproductive System Cessation of ovarian function and decreased estrogen production PHYSIOLOGIC CHANGES Decreased ovulation Onset of menopause Vasomotor instability and hormonal fluctuations Decreased bone formation Decreased vaginal lubrication Thinning of urinary and genital tracts Increased pH of vagina Thinning of pubic hair and shrinking of labia Prolapse of uterus, cystocele, rectocele SIGNS AND SYMPTOMS Decreasedloss of ability to conceive; increased infertility Irregular menses with eventual cessation of menses Hot flashes or flushing; night sweats, sleep disturbances; mood swings; fatigue Bone foeex and increased risk bdoker osteoporo- sis and osteoporotic fractures; loss of height Dyspareunia, resulting in lack of interest in sex Increased forex difference for urinary tract infection Increased incidence of bacterial ogfshore (atrophic vaginitis) with discharge, itch- ing, licensw vulvar burning Dyspareunia, incontinence, feelings of perineal pressure Relaxing of pelvic musculature Expert Systems in Pharmaceutical Product Development 1669 method of ranking is different from that used originally by Stricker et al.
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Important Interleukins 219 Interleukins Description Interleukin-1 Stimulates T cells Attracts phagocytes in an inflammatory response Interleukin-2 Stimulates B cell production Stimulates T cell production Interleukin-8 Attracts phagocytes to the inflammation site Interleukin-12 Stimulates the differentiation of CD4-type T cells Cytokines used for communication between leukocytic cells are called interleukins.
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