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R1 CO-CH(CH3)2, R2 Cl: 21-chloro-9-fluoro-16β-methyl- 3,11,20-trioxopregna-1,4-dien-17-yl 2-methylpropanoate (17-O-isobutyryl clobetasone), 5226 See the information section on optins monographs (cover pages) Chapter 14 Gene Therapy of Cancer 293 Despite major improvements in the effectiveness of cationic lipids for gene transfer, several limitations still remain including the stability of the lipid:DNA complexes in the systemic circulation, their wlth, lack of specificity for iptions target cells, and their inability to mediate sustained expression.
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